Epigenetic gene deregulation in cancer

Gene enhancer deregulation and epigenetic vulnerability

One major goal of cancer research is to identify tumor-specific mechanisms that sustain cell proliferation or survival and to develop the corresponding therapies that target selectively against tumor. Recent sequencing of primary tumor samples supports that aberration of chromatin modification and epigenetic states plays a central role in oncogenesis. For example, mutation of DNA methyltransfer...

epigenetic brca2 gene in epithelial ovarian cancer

background ovarian cancer is the most common fatal gynecologic malignancy in women. the brca2 gene has a role in regulation of cell cycle during proliferation, differentiation and dna repair. changes in the methylation of brca2 may be an effective mechanism for ovarian cancer. objectives the aim of the present study was to evaluate the association between ovarian cancer and methylation status o...

Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer.

Histone H2A.Z (H2A.Z) is an evolutionarily conserved H2A variant implicated in the regulation of gene expression; however, its role in transcriptional deregulation in cancer remains poorly understood. Using genome-wide studies, we investigated the role of promoter-associated H2A.Z and acetylated H2A.Z (acH2A.Z) in gene deregulation and its relationship with DNA methylation and H3K27me3 in prost...

Epigenetic gene silencing in cancer.

Mechanisms of epigenetic deregulation in lymphoid neoplasms.

Aberrant lymphoma epigenome is the result of a combinatorial contribution of changes in DNA methylation, histone modifications, and noncoding RNA (ncRNA) expression in lymphoma cells. All of the components of epigenome have been the focus of intense studies in various subtypes of lymphoma, which resulted in the deeper understanding of novel mechanisms of lymphomagenesis and revealed novel thera...